一本道

Pragmatic Research in Orthopedics - PRIO

Hip prosthesis in titanium with bone ingrowth. Photographer: Thor Balkhed

PRIO focuses on biological, mechanical and pharmacological aspects of fracture healing and implant osseointegration. Our translational approach aims to understand and explain complex clinical problems to improve decision making and thereby patient care.

Introduction

Bone is a unique tissue with the capacity to regenerate itself through true tissue regeneration by reactivation of embryonal processes. Implant fixation and healing of fractures are inherently related to each other on a biological level but often separated from each other in the minds of orthopedic surgeons. We are orthopedic surgeons with an interest in joint replacement and fracture treatment, anaesthesiologists, radiologists, biologists, movement scientists and others working together with national registries, the industry and academic collaborators around the world.

Hip prosthesis in titanium with bone ingrowth. Photo credit Thor BalkhedOur main focus is to improve the survival of first- time joint replacements through bone specific drugs and to improve outcome after complex joint revision surgeries with the use of morselized bonegraft, detailed pre-operative planning and evaluation of specific surgical techniques. We are interested in the pathomechanisms behind stress fractures, specifically atypical femoral fractures, the treatment and evaluation of healing and avoidance of early and late complications through implant choices guided through biomechanical understanding. Only then can we improve day-to-day practical decision making.

Our large research projects

ABOGRAFT logotype, a research project within the research group PRIO.

ABOGRAFT

Antibiotics blended into bonegraft used in hip revision surgery to prevent postoperative infection. A randomized controlled trial.
Read more here

BioFACTS

The BioFACTS study is a prospective multinational, multi-centre study involving patients with tibial fractures.

 

Research group

Principal researcher

Portr盲ttfoto av Hans Peter B枚gl.

Hans Peter Bögl
Studies healing aspects of atypical femoral fractures and the effect of fracture type and fracture fixation of femoral shaft fractures. Watch Hans Peter's author insight video .

Bild p氓 Daphne Wezenberg.
Daphne Wezenberg

Bild p氓 Lars Palm.
Lars Palm

Bild p氓 Abraham Nilsson.
Abraham Nilsson
The aim of our research is to investigate whether biomarkers can be an objective tool for diagnosing acute compartment syndrome (ACS). We also investigate whether there is a difference in tissue composition among patients with the exertional form of compartment syndrome and whether ultrasound can be used as a tool for compartment pressure measurements. 

Bild p氓 Rico Perlbach.

Rico Perlbach
Rico’s research is focused on specific surgical techniques, drugs and implant designs to improve outcome after acetabular revision and primary total hip replacement.

Bild p氓 Jonathan Brandt.
Jonathan Brandt

Bild p氓 H氓kan Ledin.
Håkan Ledin
Studies the effects of tourniquet use and bone-specific drugs on implant fixation in primary total knee- and hip replacement.

Bild p氓 Georg Zdolsek.
Georg Zdolsek
Investigates pathomechanisms that lead to the development of atypical femoral fractures, how to optimally treat and whether artificial intelligence improves the primary diagnosis of these fractures. 

Bild p氓 Andreas Meunier.

Andreas Meunier

Rickard Sand
Rickard Sand
Studying atypical femur fractures with a focus on bisphosphonate naïve patients to understand how to prevent these fractures in at-risk populations.

Publications

Senaste publikationer i LiU DiVA

2026

Rasmus Mikiver, Rickard Sand, Hans Peter B枚gl, Georg Zdolsek, Daphne Wezenberg, Karl Michaelsson, Johan Lyth, J枚rg Schilcher (2026) JBMR Plus, Vol. 10, Article ziag059 (Article in journal)
Sofia Laszlo, Anne-Mari Rosenlund, Elsa Pihl, Malfrid Holen Kristoffersen, Olof Skoldenberg, J枚rg Schilcher, Martin Eklund, Frede Frihagen, Mikael Skorpil, Kenneth B. Jonsson (2026) SPORTS MEDICINE-OPEN, Vol. 12, Article 52 (Article in journal)
Jonathan Brandt, Rico Perlbach, Johan Sk枚ld, Daphne Wezenberg, Mischa Woisetschl盲ger, J枚rg Schilcher (2026) Bone & Joint Open, Vol. 7, p. 266-274 (Article in journal)

2025

J枚rg Schilcher (2025) Acta Orthopaedica, Vol. 96, p. 584-586 (Article in journal)
Georg Zdolsek, Hans Peter Bogl, Rickard Sand, Aneta Liszka, Anna Fahlgren, J枚rg Schilcher (2025) Acta Orthopaedica, Vol. 96, p. 421-428 (Article in journal)

Research projects of our collaborators

The TrAFFiC Study

The TrAFFiC Study is investigating risk factors and identifying causes of atypical femoral fractures to find ways to prevent it.

DUALITY

The purpose of the DUALITY study is to find out whether double cups reduce the risk of dislocation after a collum fracture.

HIPSTHER

HipSTHeR – Hip Screws or (Total) Hip Replacement. The HipSTHeR study is the first randomized study in orthopedics in the world.

FFT

Fragility Fracture Trial. Zoledronate in patients with fracture - a randomized double-blind study.

Collaborative partners

Map of the world where the countries Sweden, Denmark, USA, Australia and Germany are marked. In these countries, the research group PRIO has partners.

Map of collaboration

The marked countries on the world map illustrate the research group's partners (past and future projects).

CMIV (Center for Medical Image Science and Visualization (CMIV) - Link枚ping University

Experimental Orthopedics, Link枚ping University

, University of Gothenburg


News and LinkedIn

Contact

Jörg Schilcher

Professor
Lower extremity reconstruction unit
Department of orthopedic surgery and department of biomedical and clinical sciences
University Hospital Linköping and 一本道
58185 Linköping
Phone: 0046101034291
Email: jorg.schilcher@liu.se

Organisation