Eleonore von Castelmur

Associate Professor, Docent

I use integrated structural biology techniques to gain a better understanding of the molecular mechanisms underlying protein function in health and disease

News

Two male researchers in front of a computer.

Mechanism in embryonic development makes cancer aggressive

Tumour cells in colorectal cancer exploit an important signalling pathway that normally controls embryo development. Researchers have now shown how a protein that controls limb development make colorectal cancer cells more likely to spread.

Coronavirus spurred research across disciplines

As the corona pandemic swept across the world, virologists and protein chemists rapidly joined forces and started to collaborate. Together they were able to develop ways to test the immune response after infection, and help the healthcare system.

Professor Jorma Hinkula have a discussion with two PhD students in the laboratory.

LiU scientists working on test of immune response in COVID-19

LiU scientists are working intensely to develop two different analysis methods for the immune response that follows infection by the SARS-CoV-2 virus. One of the tests is now being used by the medical care services in Region Östergötland.

Publications

2025

Amaia Jauregi Miguel, Simon S枚derholm, Tamina Weiss, Anna Nordin, Valeria Ghezzi, Salome M. Brutsch, Pierfrancesco Pagella, Yorick van de Grift, Gianluca Zambanini, Jacopo Ulisse, Alessandro Mattia, Ruslan Deviatiiarov, Elena Faustini, Lavanya Moparthi, Wenjing Zhong, Bergthor Bj枚rnsson, Per A Sandstr枚m, Erik Lundqvist, Francisca Lottersberger, Stefan Koch, Andreas E. Moor, Xiao-Feng Sun, Eleonore von Castelmur, Guojun Shengo, Claudio Cant霉 (2025) Proceedings of the National Academy of Sciences of the United States of America, Vol. 122, Article 2419691122 (Article in journal)

2023

Afshan Begum, Jun Zhang, Dean Derbyshire, Xiongyu Wu, Peter Konradsson, Per Hammarstr枚m, Eleonore von Castelmur (2023) ACS Chemical Neuroscience, Vol. 14, p. 820-828 (Article in journal)

Nghia Nguyen Thi Minh, Afshan Begum, Jun Zhang, Petter Leira, Yogesh Todarwal, Mathieu Linares, Patrick Norman, Dean Derbyshire, Eleonore von Castelmur, Mikael Lindgren, Per Hammarstr枚m, Carolin Koenig (2023) Journal of Physical Chemistry B, Vol. 127, p. 6628-6635 (Article in journal)

Bartosz Malinski, Jacopo Vertemara, Elena Faustini, Claes Ladenvall, Anna Norberg, Yuming Zhang, Eleonore von Castelmur, Panagiotis Baliakas, Renata Tisi, J枚rg Cammenga, Francisca Lottersberger (2023) Human Molecular Genetics, Vol. 32, p. 2901-2912 (Article in journal)

2022

Anna Wehlin, Irina Cornaciu, Jose Antonio Marquez, Anastassis Perrakis, Eleonore von Castelmur (2022) Journal of Structural Biology, Vol. 214, Article 107903 (Article in journal)

Anirban Sengupta, Mohammad Azharuddin, Maria Eugenia Cardona Gomez, Claudia Devito, Eleonore von Castelmur, Anna Wehlin, Zuzanna Pietras, Maria Sunnerhagen, Robert Seleg氓rd, Daniel Aili, Ali Alamer, Jorma Hinkula, Noha Al-Otaibi (2022) Vaccines, Vol. 10, Article 504 (Article in journal)

2017

Jacqueline Staring, Eleonore von Castelmur, Vincent A Blomen, Lisa G van den Hengel, Markus Brockmann, Jim Baggen, Hendrik Jan Thibaut, Joppe Nieuwenhuis, Hans Janssen, Frank J M van Kuppeveld, Anastassis Perrakis, Jan E Carette, Thijn R Brummelkamp (2017) Nature, Vol. 541, p. 412-416 (Article in journal)

2015

Thomas Zacharchenko, Eleonore von Castelmur, Daniel J Rigden, Olga Mayans (2015) Biochemical Society Transactions, Vol. 43, p. 850-5 (Article in journal)

Yoshitaka Hiruma, Carlos Sacristan, Spyridon T Pachis, Athanassios Adamopoulos, Timo Kuijt, Marcellus Ubbink, Eleonore von Castelmur, Anastassis Perrakis, Geert J P L Kops (2015) Science, Vol. 348, p. 1264-1267 (Article in journal)

2014

Barbara Franke, Alexander Gasch, Dayt茅 Rodriguez, Mohamed Chami, Muzamil M Khan, R眉diger Rudolf, Jaclyn Bibby, Akira Hanashima, Julijus Bogomolovas, Eleonore von Castelmur, Daniel J Rigden, Isabel Uson, Siegfried Labeit, Olga Mayans (2014) Open Biology, Vol. 4, Article 130172 (Article in journal)

2013

Wilco Nijenhuis, Eleonore von Castelmur, Dene Littler, Valeria De Marco, Eelco Tromer, Mathijs Vleugel, Maria H J van Osch, Berend Snel, Anastassis Perrakis, Geert J P L Kops (2013) Journal of Cell Biology, Vol. 201, p. 217-231 (Article in journal)

2012

Saskia J E Suijkerbuijk, Teunis J P van Dam, G Elif Karag枚z, Eleonore von Castelmur, Nina C Hubner, Afonso M S Duarte, Mathijs Vleugel, Anastassis Perrakis, Stefan G D R眉diger, Berend Snel, Geert J P L Kops (2012) Developmental Cell, Vol. 22, p. 1321-1329 (Article in journal)

Johan A. Strumpfer, Eleonore von Castelmur, Barbara Franke, Sonia Barbieri, Julijus Bogomolovas, Hiroshi Qadota, Petr Konarv, Dmitri Svergun, Siegfried Labeit, Klaus Schulten, Guy Benian, Olga Mayans (2012) Biophysical Journal, Vol. 102, p. 361a-362a (Article in journal)

Eleonore von Castelmur, Johan Str眉mpfer, Barbara Franke, Julijus Bogomolovas, Sonia Barbieri, Hiroshi Qadota, Petr V Konarev, Dmitri I Svergun, Siegfried Labeit, Guy M Benian, Klaus Schulten, Olga Mayans (2012) Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, p. 13608-13613 (Article in journal)

Tatjana Heidebrecht, Alexander Fish, Eleonore von Castelmur, Kenneth A Johnson, Giuseppe Zaccai, Piet Borst, Anastassis Perrakis (2012) Journal of the American Chemical Society, Vol. 134, p. 13357-13365 (Article in journal)

2010

Eric H Lee, Jen Hsin, Eleonore von Castelmur, Olga Mayans, Klaus Schulten (2010) Biophysical Journal, Vol. 98, p. 1085-1095 (Article in journal)

2008

Alexandre Urzhumtsev, Eleonore von Castelmur, Olga Mayans (2008) Acta Crystallographica Section D: Biological Crystallography, Vol. 64, p. 478-486 (Article in journal)

Michael Mrosek, Sebastian Meier, Z枚hre Ucurum-Fotiadis, Eleonore von Castelmur, Erik Hedbom, Ariel Lustig, Stephan Grzesiek, Dietmar Labeit, Siegfried Labeit, Olga Mayans (2008) Biochemistry, Vol. 47, p. 10722-10730 (Article in journal)

Eleonore von Castelmur, Marco Marino, Dmitri I Svergun, Laurent Kreplak, Z枚hre Ucurum-Fotiadis, Petr V Konarev, Alexandre Urzhumtsev, Dietmar Labeit, Siegfried Labeit, Olga Mayans (2008) Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, p. 1186-1191 (Article in journal)

2007

Michael Mrosek, Dietmar Labeit, Stephanie Witt, Heiko Heerklotz, Eleonore von Castelmur, Siegfried Labeit, Olga Mayans (2007) The FASEB Journal, Vol. 21, p. 1383-1392 (Article in journal)

von Castelmur lab

We want to explore the evolutionary relationship and functional repurposing of human proteins acquired by picornaviruses to develop new antiviral medicine and help gain better understanding of the lifecycle of these biomedically important viruses.

Image of molecules that will take you to WCMM's homepage.

Wallenberg Centre for Molecular Medicine at LiU

WCMM at LiU focuses on the medicine-technology interface, and build upon our existing strengths in research within medical technology, materials science and bioengineering.

Chemistry (KEMI)

The division's research is being performed in the areas of biochemistry, molecular biotechnology, organic chemistry, analytical chemistry, chemical engineering, inorganic chemistry and in physical chemistry, especially computational chemistry.

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